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VELTASSA is the only K+ binder with a sodium-free exchange1,2

Sodium may cause issues for your patients who cannot tolerate an increase in sodium load.

Systolic and diastolic blood pressure during 52 weeks of treatment with VELTASSA3*
Group Baseline Mean (mmHg) Week 4 Mean change from baseline (mmHg) Week 8 Mean change from baseline (mmHg) Week 52 Mean change from baseline (mmHg)
Mild HK (>5.0 to 5.5 mEq/L) 153.5/83.6 –11.2/–6.8 –14.2/–7.3 –15.7/–8.0
Moderate–severe HK (>5.5 to <6.0 mEq/L) 153.8/81.9 –8.0/–5.8 –7.9/–4.7 –17.1/–9.2

*AMETHYST-DN 52-week study (N=304).

No edema warning

The prescribing information for VELTASSA does not include a warning about edema.

Calcium and phosphate levels of VELTASSA patients

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INDICATION

VELTASSA is indicated for the treatment of hyperkalemia.

Limitation of Use: VELTASSA should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action.

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INDICATION & Important Safety Information

Important Safety Information

VELTASSA is indicated for the treatment of hyperkalemia.

Limitation of Use: VELTASSA should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action.

CONTRAINDICATIONS

VELTASSA is contraindicated in patients with a history of a hypersensitivity reaction to VELTASSA or any of its components.

INDICATION

VELTASSA is indicated for the treatment of hyperkalemia.

Limitation of Use: VELTASSA should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

VELTASSA is contraindicated in patients with a history of a hypersensitivity reaction to VELTASSA or any of its components.

WARNINGS AND PRECAUTIONS

Worsening of Gastrointestinal Motility: Avoid use of VELTASSA in patients with severe constipation, bowel obstruction or impaction, including abnormal post-operative bowel motility disorders, because VELTASSA may be ineffective and may worsen gastrointestinal conditions. Patients with a history of bowel obstruction or major gastrointestinal surgery, severe gastrointestinal disorders, or swallowing disorders were not included in clinical studies.

Hypomagnecemia: VELTASSA binds to magnesium in the colon, which can lead to hypomagnecemia. In clinical studies, hypomagnecemia was reported as an adverse reaction in 5.3% of patients treated with VELTASSA. Approximately 9% of patients in clinical trials developed hypomagnecemia with a serum magnesium value <1.4 mg/dL. Monitor serum magnesium. Consider magnesium supplementation in patients who develop low serum magnesium levels.

MOST COMMON ADVERSE REACTIONS

The most common adverse reactions (incidence ≥2%) were constipation (7.2%), hypomagnecemia (5.3%), diarrhea (4.8%), nausea (2.3%), abdominal discomfort (2.0%) and flatulence (2.0%). Mild to moderate hypersensitivity reactions were reported in 0.3% of patients treated with VELTASSA and included edema of the lips.

  1. References:
  2. Kayexalate (sodium polystyrene sulfonate) [product information]. Bridgewater, NJ: Sanofi Aventis US LLC; 2017.
  3. Lokelma® (sodium zirconium cyclosilicate) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2021.
  4. Bakris GL, Pitt B, Weir MR, et al; for AMETHYST-DN Investigators. Effect of patiromer on serum potassium level in patients with hyperkalemia and diabetic kidney disease: the AMETHYST-DN randomized clinical trial. JAMA. 2015;314(2):151–161. doi:10.1001/jama.2015.7446