VELTASSA binds K+ throughout the GI tract and acts longest in the colon, where K+ is most abundant1–4
When K+ excretion is disrupted by CKD and/or RAAS inhibition, K+ may build up in the colon.

- Na+ exchange is greatest in the ascending colon
- Normal concentration of K+ is 7x higher in the colon than in the small intestine, and K+ secretion in the colon is further upregulated in patients with CKD
- VELTASSA exchanges Ca++ for K+ where K+
is most abundant
- VELTASSA is designed to be fully ionized at the physiological pH of the colon for optimal ion exchange
- VELTASSA is designed to exchange Ca++ for K+ in the colon, where Ca++ is minimally absorbed
- After VELTASSA binds to K+, the patiromer beads are excreted through feces, leading to the removal of excess K+ from the body
VELTASSA is different from other K+ binders
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