K+ binders are not all the same
Physical and chemical properties of K+ binders4,5
|Physical and chemical properties of K+ binders4,5|
|VELTASSA (patiromer)||Kayexalate (sodium polystyrene sulfonate)||Lokelma® (sodium zirconium cyclosilicate)|
|Counterion||Calcium (Ca++)||Sodium (Na+)||Sodium (Na+) Hydrogen (H+)|
|Na+ per dose||—||1500–6000 mg||400–1200 mg|
|Dosage strengths||8.4 g, 16.8 g, 25.2 g||15–60 g||5 g, 10 g, 15 g|
|Description||Spherical, free-flowing beads||Powdered form of resin||Insoluble white powder|
Kayexalate was a registered trademark of Concordia Pharmaceuticals, Inc. Lokelma is a registered trademark of the AstraZeneca group of companies.
The uniform spherical shape, defined particle size, and low swelling ratio of VELTASSA are believed to contribute to patient tolerability.1–3
Due to their delayed onset of action, these K+ binders should not be used as monotherapy for the emergency treatment of life-threatening hyperkalemia.
No head-to-head studies have been conducted between sodium polystyrene sulfonate, sodium zirconium cyclosilicate, and patiromer; therefore, no safety or efficacy comparisons can be made.