ACEi, angiotensin converting enzyme inhibitor; ADR, adverse drug reaction; AE, adverse event; AOBP, automated office blood pressure; ARB, angiotensin II receptor blocker; BB, beta blocker; BID, twice daily; Ca2+, calcium ions; CHF, congestive heart failure; CI, confidence interval; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; GI, gastrointestinal; HF, heart failure; HK, hyperkalaemia; HTN, hypertension; K+, potassium ions; mEqL, milliequivalents per litre; RAASi, renin‐angiotensin‐aldosterone system inhibitors; rHTN, resistant hypertension; sK+, serum potassium; SPS, sodium polystyrene sulfonate; T2DM, type 2 diabetes mellitus; US, United States
Footnotes:
aLeast squares mean (95% CI) serum potassium levels over 52 weeks and during post-treatment follow-up in patients with mild or moderate hyperkalaemia (post-hoc mixed-effects models for repeated-measures analysis).1
bAt treatment day 3, there were 202 patients with mild hyperkalaemia and 82 with moderate hyperkalaemia.
cAt follow-up day 3, there were 163 patients with mild hyperkalaemia and 58 with moderate hyperkalaemia.
dAt follow-up week 1, there were 154 patients with mild hyperkalaemia and 57 with moderate hyperkalaemia.
eAt follow-up week 3, there were 126 patients with mild hyperkalaemia and 48 with moderate hyperkalaemia.
fThe recommended starting dose of Veltassa® is 8.4 g once-daily. The daily dose may be increased or decreased by 8.4 g as necessary to reach the desired target range, up to a maximum dose of 25.2 g daily.8
References:
1. Bakris GL, et al. JAMA 2015;314(2):151−61. 2. Weir MR, et al. N Engl J Med 2015;372(3):211−21. 3. Bushinsky DA, et al. Kidney Int 2015;88(6):1427−33. 4. Pitt B, et al. Eur Heart J 2011;32(7):820−8. 5. Agarwal R, et al. Lancet 2019;394(10208):1540−50. 6. Kovesdy CP, et al. Postgrad Med 2020;132:176–83. 7. Desai NR, et al. PLoS One 2020 Jan 7;15(1):e0226844. doi: 10.1371/journal.pone.0226844. 8. Veltassa® SmPC. 9. Li L, et al. J Cardiovasc Pharmacol Ther 2016;21(5):456−65. 10. Data on file, Relypsa Inc. 11. Pitt B, et al. ESC Heart Fail 2018;5(4):592−602. 12. Seferovic PM, et al. Eur J Heart Fail 2019;21:1169–86. 13. KDIGO Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease Kidney Int 2020;98(Suppl 4S):S1–S116.